Week 1 College Football Odds


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Odds and spreads have been released for the opening weekend of the 2021 College Football season following the announcement of kickoff times. Labor Day weekend is loaded with several marquee matchups that offer early betting value.

Miami will take on defending national champions Alabama at Mercedes-Benz Stadium in Atlanta on Saturday, September 4th (3:30 PM EST), while Georgia and Clemson will clash in primetime (7:30 PM EST) later in the day.

We layout the opening odds and spreads for the top matchups in Week 1 of college football.

2021 Week 1 College Football Opening Odds & Spreads

Team Spread at DraftKings Moneyline
North Carolina -6.5 (-112) -230
Virginia Tech +6.5 (-109) +180
Team Spread Moneyline
Georgia +4 (-110) +145
Clemson -4 (-110) -182
Team Spread Moneyline
Penn State +3.5 (-110) +123
Wisconsin -3.5 (-110) -155
Team Spread Moneyline
Alabama -17.5 (-110) -1000
Miami Florida +17.5 (-110) +575
Team Spread Moneyline
LSU -4.5 (-112) -200
UCLA +4.5 (-108) +155
Team Spread Moneyline
Notre Dame -9.5 (-124) -400
Florida State +9.5 (+102) +285
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